The Welsh actress, 53, shared a candid photo of her kissing the US actor and producer, 78, on Instagram to celebrate the occasion.
Michael made headlines recently when he showed off a brand new style, having dyed his hair red.
However he had a more natural look in the loved-up snap posted by Catherine.
In the post, where the mum-of-two dons a summer hat and Michael appears shirtless, she wrote: ’22 years and one day!
‘It’s in the fine details.. love you sweetheart. Happy Anniversary.’
Michael also wished his ‘darling’ wife a happy anniversary by sharing a cute photo montage of the pair on their wedding day 22 years ago.
The snaps see Catherine – in a gorgeous white dress and veil – grinning happily at the camera as Michael laughs alongside her in a smart tuxedo.
In the next, the pair share a kiss during the ceremony, which was held at the Plaza hotel in New York.
He captioned the post on Instagram: ‘Happy Anniversary to my darling Catherine! I love you so much @catherinezetajones #22years.’
Friends and fans offered their congratulations to the couple on the milestone, with Zeta-Jones simply replying to Douglas in the comments by saying “Love you”.
The Hollywood stars have been married since 2000, having first met at the Deauville Film Festival in France in August 1998.
They have two children together: Dylan, 22, and 19-year-old Carys.
Their love may have been written in the stars as they also share the same birthday, having both been born on September 25 – though 25 years apart.
Major Hollywood star Catheerine got her big break in the early 1990s in TV series The Darling Buds Of May and went on to star on stage and screen, and in 2002 won an Oscar for her role in Chicago.
Michael has also had a hugely successful career as an actor and producer, with his role as Gordon Gekko in 1987’s Wall Street winning him the Oscar for best actor.
He has also held starring roles in some of the most iconic thrillers of the last few decades, including Fatal Attracton with Glenn Close and Basic Instinct with Shaaron Stone.
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